Some people are highly reactive
Geoff Whaling
My Mum is severely affected by many of our Australian Grevilleas including Southern Silky Oak (SSO - Grevillea robusta) and many of the garden ornamentals like "Robyn Gordon" - http://anpsa.org.au/APOL2009/mar09-s1.html
Any contact, even a brush against plant material in a garden or flowers in a floral arrangement, or with dust and fine wood shavings brings out a very irritating and quite painful dermatitis rash that alarmingly spreads quite quickly.
Curiously we have observed her handling items made from SSO that have been finished but she was unaware what the timber was. No reaction.
My thoughts are that if the finish is a film barrier then there is less chance of contact with the allergens pentadecylresorcinol and tridecylresorcinol.
Many years ago I was approached by a body piercing enthusiast to custom make a range of ear plugs for body stretching for him to sell to others from you guessed it Cocobolo & other exotic woods. I did my research and passed up what could have been a very good earner - BUT not worth the risk.
I believe that sensitivity to contact dermatitis can be triggered by cumulative exposure.
This is an interesting read about a contact allergy to cocobolo wood worn as a bracelet - http://www.medscape.com/viewarticle/516056_2 also a report of occupational exposure http://www.ncbi.nlm.nih.gov/pubmed/14749027
Perhaps book marks with a solid film finish are low risk but there is the distinct possibility that they could be handled for long periods of time by the reader.
I don't see much Cocobolo though I have a nice sample 2" square x 12" long piece sitting here along with a few other exotics waiting for me to play with them.
One thing we can be sure of is that we know very little about the chemical composition of many of our timbers. What gives them the unique aromatics, or the timber preservation characteristics, or pest resistance, or even the medicinal qualities known to many native peoples is slowly being discovered through research.